doi: 10.1084/jem.126.6.1013.
Enharncement of the hemolytic activity of the second component of human complement by oxidation
- PMID: 4964564
- PMCID: PMC2138419
- DOI: 10.1084/jem.126.6.1013
Item in Clipboard
Enharncement of the hemolytic activity of the second component of human complement by oxidation
J Exp Med.
.
Abstract
A method has been described for the chemical modification of human C'2 which results in a pronounced enhancement of its hemolytic activity and a marked increase in the stability of the intermediate complex EAC'1a,4,2a prepared with the modified C'2. Both effects are fully explained by the observed increase in activity and stability of the C'3 converting enzyme, C'4,2a, following its generation with modified C'2. Evidence has been presented in support of the hypothesis that the modification resulting from treatment of C'2 with a critical concentration of iodine consists of oxidation of one or more sulfhydryl group within the molecule.
Similar articles
-
Complement as a mediator of inflammation. 3. Purification of the activity with anaphylatoxin properties generated by interaction of the first four components of complement and its identification as a cleavage product of C'3.J Exp Med. 1967 Dec 1;126(6):1027-48. doi: 10.1084/jem.126.6.1027. J Exp Med. 1967. PMID: 6069927 Free PMC article.
-
THE ROLE OF THE COMPONENTS OF COMPLEMENT IN SPECIFIC IMMUNE FIXATION.J Exp Med. 1942 Apr 1;75(4):421-35. doi: 10.1084/jem.75.4.421. J Exp Med. 1942. PMID: 19871194 Free PMC article.
-
Formation and functional significance of a molecular complex derived from the second and the fourth component of human complement.J Exp Med. 1967 Feb 1;125(2):359-80. doi: 10.1084/jem.125.2.359. J Exp Med. 1967. PMID: 6019133 Free PMC article.
-
Chemistry and reaction mechanisms of complement.Adv Immunol. 1968;8:1-80. doi: 10.1016/s0065-2776(08)60464-2. Adv Immunol. 1968. PMID: 4174135 Review. No abstract available.
-
The laboratory substitutes of the red cell of paroxysmal nocturnal haemoglobinuria (PNH): PNH-like red cells.Ser Haematol. 1972;5(3):137-75. Ser Haematol. 1972. PMID: 4565711 Review. No abstract available.
Cited by
-
Isolation and analysis of the mechanism of action of an inactivator of C4b in normal human serum.J Exp Med. 1975 Apr 1;141(4):890-903. J Exp Med. 1975. PMID: 47888 Free PMC article.
-
Formation in the presence of C3 nephritic factor (C3NeF) of an alternative pathway C3 convertase containing uncleaved B.Immunology. 1976 Nov;31(5):789-96. Immunology. 1976. PMID: 992711 Free PMC article.
-
Properdin- and nephritic factor-dependent C3 convertases: requirement of native C3 for enzyme formation and the function of bound C3b as properdin receptor.J Exp Med. 1975 Sep 1;142(3):760-72. doi: 10.1084/jem.142.3.760. J Exp Med. 1975. PMID: 1165475 Free PMC article.
-
Release of trapped marker from liposomes by the action of purified complement components.Proc Natl Acad Sci U S A. 1969 Sep;64(1):290-5. doi: 10.1073/pnas.64.1.290. Proc Natl Acad Sci U S A. 1969. PMID: 5263014 Free PMC article.
-
Solubilization of an activity regulating C3b function from Raji cell membranes.Immunology. 1982 May;46(1):163-73. Immunology. 1982. PMID: 7042548 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
