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. 1979 Jul 15;182(1):189-93.
doi: 10.1042/bj1820189.

Uptake and degradation of mast-cell granules by mouse peritoneal macrophages

U Lindahl, H Pertoft, R Seljelid

Uptake and degradation of mast-cell granules by mouse peritoneal macrophages

U Lindahl et al. Biochem J. .

Abstract

35S-labelled mast-cell granules isolated from mouse mastocytomas were added to mouse macrophages in vitro. The granules were avidly phagocytosed, and subsequently the radioactivity was released to the medium as inorganic [35S]sulphate. After pulse-labelling, a total of about 80% of the cell-associated radioactivity was thus released in the course of 24 h, indicating an extensive breakdown of the sulphated polysaccharides, mainly heparin, present in the granules. The uptake of the mast-cell granules caused pronounced, but reversible, spreading of the macrophages.

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