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. 1979 Oct;40(4):608-14.
doi: 10.1038/bjc.1979.226.

Bovine ocular squamous-cell carcinoma: lymphocyte response to phytohaemagglutinin and tumour antigen

P A Jennings, M F Lavin, D J Hughes, P B Spradbrow
Free PMC article

Bovine ocular squamous-cell carcinoma: lymphocyte response to phytohaemagglutinin and tumour antigen

P A Jennings et al. Br J Cancer. 1979 Oct.
Free PMC article

Abstract

The presence of ocular squamous-cell carcinomas in cattle was associated with significantly lower blastogenic response of peripheral-blood cultures to PHA than that of age-matched control cattle. The difference in blastogenic response was more marked when the external diameter of the tumour exceeded 2 cm. Cattle with aquamous-cell carcinomas had cell-mediated immunity against tumour extracts, as measured by the leucocyte adherence inhibition (LAI) microassay. The LAI reaction against tumour extracts was directly proportional to the general level of cell-mediated immunity as demonstrated by the lymphoproliferative response to PHA.

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