A preliminary study of the effect of pyridoxine administration in a subgroup of hyperkinetic children: a double-blind crossover comparison with methylphenidate
- PMID: 497303
A preliminary study of the effect of pyridoxine administration in a subgroup of hyperkinetic children: a double-blind crossover comparison with methylphenidate
Abstract
A small sample of six patients with the putative "hyperkinetic syndrome" participated in a research protocol comparing administration of pyridoxine, methylphenidate, and placeboes. The children had had low whole blood serotonin levels and a history of previous responsiveness to methylphenidate. The results of the double-blind clinical evaluation showed trends suggesting that both pyridoxine and methylphenidate were more effective than placebo in suppressing the symptoms of hyperkinesis. Pyridoxine elevated whole-blood serotonin levels, methylphenidate did not. Clinical and laboratory evidence indicated that the pyridoxine effects persisted after the 3-week period when the vitamin had been given in this experimental design.
Similar articles
-
The effect of pyridoxine hydrochloride on blood serotonin and pyridoxal phosphate contents in hyperactive children.Pediatrics. 1975 Mar;55(3):437-41. Pediatrics. 1975. PMID: 1143984
-
The effect of methylphenidate on sensory perception in varying degrees of hyperkinetic behaviour.Dis Nerv Syst. 1975 Jun;36(6):286-8. Dis Nerv Syst. 1975. PMID: 1097220 Clinical Trial.
-
Methylphenidate in hyperkinetic children: differences in dose effects on impulsive behavior.Pediatrics. 1979 Oct;64(4):408-11. Pediatrics. 1979. PMID: 492804 Clinical Trial.
-
[Hyperkinetic syndrome and diet--a therapeutic alliance? (author's transl)].Klin Padiatr. 1980 May;192(3):179-85. doi: 10.1055/s-2008-1035580. Klin Padiatr. 1980. PMID: 7001143 Review. German.
-
What have we learned from psychoactive drug research on hyperactives?Am J Dis Child. 1972 Feb;123(2):177-80. doi: 10.1001/archpedi.1972.02110080155025. Am J Dis Child. 1972. PMID: 4554552 Review. No abstract available.
Cited by
-
Vitamin therapy in the absence of obvious deficiency. What is the evidence?Drugs. 1984 Feb;27(2):148-70. doi: 10.2165/00003495-198427020-00003. Drugs. 1984. PMID: 6230219 Review.
-
A closer look at the role of nutrition in children and adults with ADHD and neurodivergence.Front Nutr. 2025 Jul 30;12:1586925. doi: 10.3389/fnut.2025.1586925. eCollection 2025. Front Nutr. 2025. PMID: 40808843 Free PMC article.
-
SHR/NCrl rats as a model of ADHD can be discriminated from controls based on their brain, blood, or urine metabolomes.Transl Psychiatry. 2021 Apr 22;11(1):235. doi: 10.1038/s41398-021-01344-4. Transl Psychiatry. 2021. PMID: 33888684 Free PMC article.
-
Brief report: an open middle-term study of combined vitamin B6-magnesium in a subgroup of autistic children selected on their sensitivity to this treatment.J Autism Dev Disord. 1988 Sep;18(3):435-47. doi: 10.1007/BF02212198. J Autism Dev Disord. 1988. PMID: 3170459 No abstract available.
-
High-dose pyridoxine and magnesium administration in children with autistic disorder: an absence of salutary effects in a double-blind, placebo-controlled study.J Autism Dev Disord. 1997 Aug;27(4):467-78. doi: 10.1023/a:1025861522935. J Autism Dev Disord. 1997. PMID: 9261669 Clinical Trial.