doi: 10.1111/j.1476-5381.1979.tb08690.x.
The effects of ions on the binding of agonists and antagonists to muscarinic receptors
- PMID: 497538
- PMCID: PMC2043948
- DOI: 10.1111/j.1476-5381.1979.tb08690.x
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The effects of ions on the binding of agonists and antagonists to muscarinic receptors
Br J Pharmacol.
1979 Nov.
Abstract
1 There are no selective effects of Na+, K+, Ca2+, Mg2+ or Cl- on the binding of antagonists or agonists to muscarinic receptors in rat brain. A decrease in affinity related to ionic strength is found for all these ions. 2 Larger effects were produced by T1+, La3+, and some transition metal ions.
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