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. 1979 Nov;67(3):371-7.
doi: 10.1111/j.1476-5381.1979.tb08690.x.

The effects of ions on the binding of agonists and antagonists to muscarinic receptors

N J Birdsall, A S Burgen, E C Hulme, J W Wells

The effects of ions on the binding of agonists and antagonists to muscarinic receptors

N J Birdsall et al. Br J Pharmacol. 1979 Nov.

Abstract

1 There are no selective effects of Na+, K+, Ca2+, Mg2+ or Cl- on the binding of antagonists or agonists to muscarinic receptors in rat brain. A decrease in affinity related to ionic strength is found for all these ions. 2 Larger effects were produced by T1+, La3+, and some transition metal ions.

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References

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