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Clinical Trial
. 1969 Jun 1;129(6):1385-95.
doi: 10.1084/jem.129.6.1385.

Human immunity to the meningococcus. V. The effect of immunization with meningococcal group C polysaccharide on the carrier state

E C Gotschlich, I Goldschneider, M S Artenstein
Clinical Trial

Human immunity to the meningococcus. V. The effect of immunization with meningococcal group C polysaccharide on the carrier state

E C Gotschlich et al. J Exp Med. .

Abstract

Purified meningococcal polysaccharides were administered to army recruits. No adverse reactions were observed in 145 men who received group C polysaccharide, and in 53 men who were injected with group A polysaccharide. Hemagglutinating and bactericidal activity developed in the sera of all individuals with the exception of two recruits injected with A polysaccharide. During the 6 wk period of observation, the proportion of unvaccinated recruits who acquired group C meningococci in the three companies studied was 38, 42, and 69 per cent. A significantly lower proportion of the individuals vaccinated with group C polysaccharide acquired group C meningococci; 4.6, 24, and 31 per cent respectively.

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