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. 1969 Feb;62(2):514-20.
doi: 10.1073/pnas.62.2.514.

A template-selective inhibitor of in vitro transcription

D L Wilson, E P Geiduschek

A template-selective inhibitor of in vitro transcription

D L Wilson et al. Proc Natl Acad Sci U S A. 1969 Feb.

Abstract

A macromolecular factor, TF1, has been isolated from bacteriophage SP01-infected B. subtilis. TF1 selectively inhibits in vitro transcription of SP01 and related viral DNA. Evidence is presented regarding these properties of the repressor-like TF1: (1) template and conformational specificity; (2) interaction with DNA rather than RNA polymerase; (3) trypsin sensitivity; (4) reversibility of action; and (5) ability to block initiation, but not propagation, of RNA synthesis.

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References

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