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. 1969 Sep;42(3):706-14.
doi: 10.1083/jcb.42.3.706.

Intestinal capillaries. II. Structural effects ofEDTA and histamine

F Clementi, G E Palade

Intestinal capillaries. II. Structural effects ofEDTA and histamine

F Clementi et al. J Cell Biol. 1969 Sep.

Abstract

Perfusion of the fenestrated capillaries of the intestinal mucosa of the rat with 0.05-0.1 M EDTA removes the diaphragms of the endothelial cells and detaches these cells from one another and from the basement membrane. The latter, even when completely denuded, retains effectively particles of 340 A (average) diameter. Perfusion with histamine (1 microg/ml) results in partial removal of fenestral diaphragms, occasional detachment of the endothelium from the basement membrane, and focal separation of endothelial intercellular junctions.

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References

    1. Circulation. 1961 Aug;24:368-88 - PubMed
    1. J Biophys Biochem Cytol. 1961 Feb;9:409-14 - PubMed
    1. Lab Invest. 1967 Jul;17(1):39-60 - PubMed
    1. J Cell Biol. 1967 Oct;35(1):213-36 - PubMed
    1. Am J Pathol. 1965 Apr;46:589-620 - PubMed