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. 1979 Nov;39(11):4356-63.

In vitro cytokinetic response of human colon cancer cells to cis-dichlorodiammineplatinum(II)

J P Bergerat, B Barlogie, W Göhde, D A Johnston, B Drewinko
  • PMID: 498069

In vitro cytokinetic response of human colon cancer cells to cis-dichlorodiammineplatinum(II)

J P Bergerat et al. Cancer Res. 1979 Nov.

Abstract

The cytokinetic response of a human colon carcinoma cell line to cis-dichlorodiammineplatinum(II) was investigated using flow cytometry of DNA content, autoradiography after pulse and continuous tritiated thymidine exposure, and mitotic accumulation after continuous Colcemid treatment. With increasing concentration and exposure time, cis-dichlorodiammineplatinum(II) delayed and then blocked cycle traverse in S and G2 phases. After prolonged treatment with high concentrations of cis-dichlorodiammineplatinum(II), an additional block in G1 or at the G1-S boundary was established. Irreversibility of cell cycle distribution changes after prolonged observation periods suggests cell death in G2, S, and G1 compartments.

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