Correlation between glucocorticoid receptor and cytolytic response of murine lymphoid cell lines
- PMID: 498102
Item in Clipboard
Correlation between glucocorticoid receptor and cytolytic response of murine lymphoid cell lines
Cancer Res.
1979 Nov.
Abstract
By fusion between murine thymoma lines which are either homozygous (r+/r+ or r-/r-) or hemizygous (r+/r-) for the glucocorticoid receptor structural gene r, hybrid clones have been obtained which carry one, two three, or four copies of the r+ allele. These hybrids contain different amounts of normal glucocorticoid receptor as the result of a r+ gene dosage effect. Measurements of the cytolytic response of these hybrids to dexamethasone indicate a tight correlation between receptor content and sensitivity.
Similar articles
-
Glucorticoid resistance in murine lymphoma and thymoma lines.Cancer Res. 1978 Nov;38(11 Pt 2):4279-84. Cancer Res. 1978. PMID: 698966
-
Characterization of a new type of thymoma variants supersensitive to dexamethasone.J Steroid Biochem. 1981 Dec;15:25-34. doi: 10.1016/0022-4731(81)90254-5. J Steroid Biochem. 1981. PMID: 7339252 No abstract available.
-
Glucocorticoid-induced lymphocytolysis: state of the genetic analysis.J Supramol Struct. 1980;13(3):401-10. doi: 10.1002/jss.400130311. J Supramol Struct. 1980. PMID: 7206713
-
Induction of glucocorticoid-resistant variants in a murine thymoma line by antitumor drugs.Cancer Res. 1981 Nov;41(11 Pt 1):4540-6. Cancer Res. 1981. PMID: 7306975
-
Glucocorticoid receptors and steroid sensitivity in normal and neoplastic human lymphoid tissues: a review.Cancer Res. 1984 Feb;44(2):431-7. Cancer Res. 1984. PMID: 6362849 Review.
Cited by
-
Effects of dexamethasone on the growth of cultured rabbit articular chondrocytes:relation with the nuclear glucocorticoid-receptor complex.Ann Rheum Dis. 1987 Feb;46(2):146-52. doi: 10.1136/ard.46.2.146. Ann Rheum Dis. 1987. PMID: 2435251 Free PMC article.
-
Gamma interferon down-regulates glucocorticoid receptor expression and attenuates hormone action in a human osteosarcoma cell line.Endocrine. 1995 Oct;3(10):737-42. doi: 10.1007/BF03000206. Endocrine. 1995. PMID: 21153163
-
TNF-alpha and glucocorticoid receptor interaction in L6 muscle cells: a cooperative downregulation of myosin heavy chain.Steroids. 2007 Sep;72(9-10):705-12. doi: 10.1016/j.steroids.2007.05.007. Epub 2007 Jun 2. Steroids. 2007. PMID: 17624386 Free PMC article.
-
Spinal Epidural Lipomatosis: A Comprehensive Review.Orthop Rev (Pavia). 2021 Jul 11;13(2):25571. doi: 10.52965/001c.25571. eCollection 2021. Orthop Rev (Pavia). 2021. PMID: 34745483 Free PMC article. Review.
-
Transcriptional transactivation functions localized to the glucocorticoid receptor N terminus are necessary for steroid induction of lymphocyte apoptosis.Mol Cell Biol. 1992 Feb;12(2):589-97. doi: 10.1128/mcb.12.2.589-597.1992. Mol Cell Biol. 1992. PMID: 1310148 Free PMC article.