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. 1969 Dec 5;166(3910):1306-7.
doi: 10.1126/science.166.3910.1306.

Morphine: conditioned increases in self-administration in rhesus monkeys

S R Goldberg, J H Woods, C R Schuster

Morphine: conditioned increases in self-administration in rhesus monkeys

S R Goldberg et al. Science. .

Abstract

Operant responding in three monkeys was maintained by intravenous presentations of morphine. Nalorphine produced reliable increases in morphine-reinforced responding. With successive daily nalorphine injections there was a decreased latency of self-administration responding for morphine, and substituted saline injections produced conditioned increases in morphine-reinforced responding.

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