Sensitization of guinea-pigs to measles vaccines

Abstract

Attenuated measles virus vaccine of chick embryo tissue culture origin and unadsorbed inactivated measles vaccines derived from monkey kidney tissue culture produced little or no sensitization of guinea-pigs, as monitored by the Schultz–Dale or passive cutaneous anaphylaxis techniques. Inactivated vaccines of both monkey kidney and chick embryo tissue culture origins were sensitizing when they contained a mineral adjuvant. The sensitizing activity was also present in the aqueous phase of Tween 80–ether-treated measles virus fluid and in uninfected tissue cultures of simian, avian and human origins.