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. 1969;41(3):623-8.

The roles of early alert and of adjuvant in the control of Hong Kong influenza by vaccines

M R Hilleman

The roles of early alert and of adjuvant in the control of Hong Kong influenza by vaccines

M R Hilleman. Bull World Health Organ. 1969.

Abstract

The major antigenic changes in influenza A virus that occur at 10-year intervals reduce the effectiveness of existing vaccines and pose a problem for the control of pandemics by vaccination. These difficulties may be obviated in two ways. First, by detecting the emergence of a new variant sufficiently ahead of its general spread for it to be possible to produce a corresponding vaccine in good time; the World Health Organization is widely depended upon for this early warning. Secondly, by the improvement of existing vaccines to increase and broaden their antigenicity; here, their modification by, for instance, adjuvant 65 may contribute significantly.

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