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Comparative Study
. 1979 Nov;26(5):611-7.
doi: 10.1002/cpt1979265611.

Sulfinpyrazone kinetics after intravenous and oral administration

J B Lecaillon, C Souppart, J P Schoeller, G Humbert, P Massias
Comparative Study

Sulfinpyrazone kinetics after intravenous and oral administration

J B Lecaillon et al. Clin Pharmacol Ther. 1979 Nov.

Abstract

Sulfinpyrazone kinetics has been investigated after intravenous and oral doses. They may be described by a 3-compartment open model. In the body about half the drug is in the plasma or in interstitial fluids, which equilibrated with plasma. Most of the rest is in an extravascular compartment, from which it easily diffuses back to the plasma. About 3% of the dose is still in the body after 24 hr and is located mainly in a deep compartment. After oral administration, sulfinpyrazone is quickly absorbed, largely from the stomach.

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