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. 1967 Oct;1(5):980-7.
doi: 10.1128/JVI.1.5.980-987.1967.

Physicochemical characterization of adeno-associated satellite virus type 4 and its nucleic acid

W P Parks, M Green, M Piña, J L Melnick

Physicochemical characterization of adeno-associated satellite virus type 4 and its nucleic acid

W P Parks et al. J Virol. 1967 Oct.

Abstract

Based on protein, deoxyribonucleic acid (DNA), and phosphorus analyses, adeno-associated satellite virus type 4 has a DNA content of 26.5%, significantly larger than type 1 which contains 18.9% DNA. Type 4 DNA contains 58 to 62% guanine + cytosine, as calculated from thermal denaturation temperature and buoyant density measurements. Simian adenovirus SV15, which serves as a helper virus for type 4 satellite, contains 13.7% DNA with a guanine + cytosine content of 55 to 57%. The DNA extracted from type 4 satellite virus is a linear, double-stranded molecule, as shown by thermal denaturation temperature profile measurements and by electron microscopy. The contour length and sedimentation coefficient of type 4 DNA indicate a molecular weight of 3.0 x 10(6) daltons.

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