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. 1970 Jul 17;169(3942):289-90.
doi: 10.1126/science.169.3942.289.

Plasmodium falciparum in owl monkeys: drug resistance and chloroquine binding capacity

C D Fitch

Plasmodium falciparum in owl monkeys: drug resistance and chloroquine binding capacity

C D Fitch. Science. .

Abstract

Erythrocytes infected with chloroquine-sensitive Plasmodium falciparum bind chloroquine with an apparent intrinsic association constant of 1.5 x 10(7) liters per mole. Such high-affinity binding of chloroquine is absent or deficient in uninfected erythrocytes and in erythrocytes infected with chloroquine-resistant Plasmodium falciparum.

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