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. 1970 Sep;67(1):164-71.
doi: 10.1073/pnas.67.1.164.

Epidermal growth factor: high and low molecular weight forms

J M Taylor, S Cohen, W M Mitchell

Epidermal growth factor: high and low molecular weight forms

J M Taylor et al. Proc Natl Acad Sci U S A. 1970 Sep.

Abstract

In crude homogenates of the submaxillary gland of the male mouse, epidermal growth factor (EGF) activity was found almost entirely in a high molecular weight complex (about 74,000 daltons). This high molecular weight form may be reversibly dissociated into EGF and an EGF-binding protein. EGF was found to have a molecular weight of approximately 6400. The EGF-binding protein has a molecular weight of 29,000, and shows arginyl-esterase activity.

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