Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1970 Nov;20(5):754-6.
doi: 10.1128/am.20.5.754-756.1970.

Effect of pH on the activity of erythromycin against 500 isolates of gram-negative bacilli

V Lorian, L D Sabath

Effect of pH on the activity of erythromycin against 500 isolates of gram-negative bacilli

V Lorian et al. Appl Microbiol. 1970 Nov.

Abstract

Erythromycin was found to be a more effective inhibitor of gram-negative bacilli in alkaline medium than in neutral or acid medium. A definite effect was noted with all of 500 recent clinical isolates of Escherichia coli, Klebsiella-Enterobacter, Pseudomonas aeruginosa, and Proteus mirabilis studied, but it was most striking with E. coli. At pH 8.5 all strains, except for 14% of those of P. mirabilis, were inhibited by concentrations of erythromycin readily achieved in urine with common therapeutic doses.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Br Med J. 1956 Jul 14;2(4984):61-5 - PubMed
    1. Antibiot Chemother (Northfield). 1962 Mar;12:169-72 - PubMed
    1. Proc Soc Exp Biol Med. 1952 Oct;81(1):118-21 - PubMed
    1. Appl Microbiol. 1968 Sep;16(9):1288-92 - PubMed
    1. Antimicrob Agents Chemother (Bethesda). 1969;9:413-6 - PubMed

MeSH terms

LinkOut - more resources