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. 1970 Nov;20(5):754-6.
doi: 10.1128/am.20.5.754-756.1970.

Effect of pH on the activity of erythromycin against 500 isolates of gram-negative bacilli

V Lorian, L D Sabath

Effect of pH on the activity of erythromycin against 500 isolates of gram-negative bacilli

V Lorian et al. Appl Microbiol. 1970 Nov.

Abstract

Erythromycin was found to be a more effective inhibitor of gram-negative bacilli in alkaline medium than in neutral or acid medium. A definite effect was noted with all of 500 recent clinical isolates of Escherichia coli, Klebsiella-Enterobacter, Pseudomonas aeruginosa, and Proteus mirabilis studied, but it was most striking with E. coli. At pH 8.5 all strains, except for 14% of those of P. mirabilis, were inhibited by concentrations of erythromycin readily achieved in urine with common therapeutic doses.

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