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. 1979 Sep;16(3):189-94.
doi: 10.1007/BF00562060.

Influence of the defective metabolism of sparteine on its pharmacokinetics

M Eichelbaum, N Spannbrucker, H J Dengler

Influence of the defective metabolism of sparteine on its pharmacokinetics

M Eichelbaum et al. Eur J Clin Pharmacol. 1979 Sep.

Abstract

Sparteine is metabolized by N1-oxidation, which in some subjects is defective. The defect has a pronounced effect on the kinetics of the drug. In nonmetabolisers elimination of sparteine proceeds entirely via renal excretion by a capacity-limited process, 99,9% of the dose being excreted as unchanged drug. In metabolisers the drug is mainly eliminated by metabolic degradation. Pronounced differences in beta-phase half-life and total plasma clearance were observed between metabolisers (156 min; 535 ml . min-1) and nonmetabolisers (409 min; 180 ml . min-1).

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