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. 1971 Jan;68(1):182-6.
doi: 10.1073/pnas.68.1.182.

DNA polymerase activities in varions of visna virus, a causative agent of a "slow" neurological disease

J Schlom, D H Harter, A Burny, S Spiegelman

DNA polymerase activities in varions of visna virus, a causative agent of a "slow" neurological disease

J Schlom et al. Proc Natl Acad Sci U S A. 1971 Jan.

Abstract

The presence is reported of an RNA-instructed DNA polymerase in visna virus, the causative agent of a "slow" neurological disease in sheep. The product synthesized by the RNA-directed reaction has been shown to be a DNA heteropolymer by the following criteria: synthesis requires the presence of all four deoxyriboside triphosphates; the product is resistant to ribonuclease and alkali but is degraded by DNase; and the product has a density of 1.420 in Cs(2)SO(4) solution, characteristic of DNA.Visna virions, like those of the oncogenic RNA viruses, contain DNA polymerase activities that respond to a variety of double-stranded DNAs and to synthetic DNA.RNA hybrids.

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