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. 1979 Sep 15;58(2):207-10.
doi: 10.1016/0014-2999(79)90014-1.

Dihydralazine and catecholamine-synthesizing enzymes in spontaneous hypertension

L Denoroy, B Renaud, M Vincent, J Sacquet, J Sassard

Dihydralazine and catecholamine-synthesizing enzymes in spontaneous hypertension

L Denoroy et al. Eur J Pharmacol. .

Abstract

Dihydralazine treatment which lowered blood pressure in young rats from the Lyon Hypertensive Strain (LHS), did not change phenylethanolamine-N-methyltransferase (PNMT) activity, but decreased tyrosine hydroxylase and dopamine-beta-hydroxylase activities in the C2 medullary region. These data suggest that the increase in PNMT activity, previously described for this strain, is not a consequence of the developing hypertension and that hypotensive treatment could inactivate some catecholaminergic neurons of the medulla oblongata.

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