[Dopaminergic component in the mechanism of action of gamma-aminobutyric acid derivatives and structural analogs]

Abstract

In experiments on rats and male mice the GABA derivatives fenibut, fepiron and the organosilicon compound N-methyl (3-trimethylsilil)pyrrolidone (IA) antagonized apomorphine sterotypy and aggressiveness. Fenibut and IA potentiated haloperidol catalepsy. Fenibut, fepiron, sodium hydroxybutyrate and IA also antagonized the effects of phenamine. The biochemical investigations have shown that fenibut and IA produce acceleration of the intraneuronal synthesis and catabolism of DA. It is suggested that the behavioral effects of the GABA derivatives are partly relative to inhibition of the dopamin--ergic system.