[Poison content in the blood and tissues of mammals after the inhalational uptake of carbon monoxide and benzene and cyanide vapors]

Abstract

The time of retention in the body of albino mice, hamsters, albino rats, guinea pigs, rabbits, cats and dogs of carbon oxide benzene and methylcyanide was analyzed. The amount of poison was determined by spectrophotometry and gas chromatography every 4 and 24 hours following inhalation. Conclusions are drawn about constancy of the poison half life for each animal species. Two phases of the poison elimination were determined: rapid (up to 5 hours) and slow (up to several days). The poison elimination rate directly correlated with the pulse rate, respiration and oxygen consumption per unit body weight in all animals, reverse dependence on the body weight being recorded only in albino mice, hamsters, albino rats and guinea pigs.