Preliminary immunologic characterization of glycoprotein antigens (CEA) of tumors of gastrointestinal tract in humans
- PMID: 50054
Preliminary immunologic characterization of glycoprotein antigens (CEA) of tumors of gastrointestinal tract in humans
Abstract
Using the method of double diffusion in agar and precipitation, inhibition test and specific antitumor immune sera, perchloric extracts of carcinomas of the stomach and lower parts of the gastrointestinal tract were found to contain a carcinoembryonic antigen with electrophoretic mobility of gamma-globulins. Antigens from carcinomas of all studied parts of the gastrointestinal tract (stomach, sigmoid, colon and rectum) gave lines of identity in the test of double diffusion in agar. This antigen was not demonstrable in the mucous membranes surrounding the carcinomas of the gastrointestinal tract or in normal organs (gastrointestinal mucosa, liver, kidneys, spleen, plasma), or in perchloric extracts of gastrointestinal tissues of human fetuses.
Similar articles
-
Immunohistological localization of carcinoembryonic antigen and nonspecific cross-reacting antigen in gastrointestinal normal and tumoral tissues.Cancer Res. 1973 Dec;33(12):3299-305. Cancer Res. 1973. PMID: 4586525 No abstract available.
-
Introductory immunologic studies on human gastrointestinal tract tumors.Arch Immunol Ther Exp (Warsz). 1973;21(6):849-61. Arch Immunol Ther Exp (Warsz). 1973. PMID: 4131722 No abstract available.
-
Immunologic diagnosis of human digestive tract cancer. Carcinoembryonic antigens.Am J Gastroenterol. 1973 Mar;59(3):233-43. Am J Gastroenterol. 1973. PMID: 4121819 Review. No abstract available.
-
[Demonstration of common antigenic determinants between the carcinoembryonic antigen of the digestive tract and a glycoprotein extract of normal tissues].Schweiz Med Wochenschr. 1972 Aug 19;102(33):1157-61. Schweiz Med Wochenschr. 1972. PMID: 4115517 French. No abstract available.
-
Nature and significance of the antigens associated with human gastrointestinal tumours.J Clin Pathol Suppl (R Coll Pathol). 1974;7:115-8. J Clin Pathol Suppl (R Coll Pathol). 1974. PMID: 4598346 Free PMC article. Review. No abstract available.