Haemodynamic effects of oral aminorex and amphetamine in unanaesthetized beagle dogs

Abstract

The haemodynamic effects of four daily oral doses of 1·5 mg/kg of aminorex (as fumarate) were measured in unanaesthetized beagle dogs. A similar study was performed in another group of related animals using d-amphetamine sulphate (1 mg/kg). Both agents produced similar sympathomimetic effects consisting of transient rises in systemic and pulmonary arterial blood pressures over an eight-hour period after administration of either drug. Heart rate remained unchanged in the dogs receiving aminorex whereas it decreased in those receiving amphetamine.

There was no cumulative or residual haemodynamic effect of either drug. We therefore conclude that neither aminorex nor amphetamine readily produces sustained pulmonary hypertension in beagle dogs.