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. 1972 Apr 1;135(4):985-96.
doi: 10.1084/jem.135.4.985.

Lymphoid cells in delayed hypersensitivity. 3. The influence of x-irradiation on passive transfer and on in vitro production of soluble mediators

S B Salvin, J Nishio

Lymphoid cells in delayed hypersensitivity. 3. The influence of x-irradiation on passive transfer and on in vitro production of soluble mediators

S B Salvin et al. J Exp Med. .

Abstract

X-irradiation up to 480 R does not inhibit either adoptive transfer of delayed hypersensitivity or production in vitro of soluble mediators, such as migration-inhibitory factor (MIF). Above that dosage and as high as 3000 R, adoptive transfer is inhibited, but production of MIF is not. An increase in skin response occurred when 24-48 hr were allowed to elapse after intravenous transfer and before skin testing. Treatment of recipients with colchicine at the time of adoptive transfer inhibited the development of a skin reaction to specific antigen.

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