Effect of various factors on induction of liver tumors in animals by the alpha-isomer of benzene hexachloride
- PMID: 50248
Effect of various factors on induction of liver tumors in animals by the alpha-isomer of benzene hexachloride
Abstract
The tumorigenic effect of a diet containing the alpha-isomer of benzene hexachloride (alpha-BHC) on the liver of various animals was examined. It was found that alpha-BHC induced liver tumors in male and female mice but not in rats or hamsters in the present observations. Histological changes in the liver of mice induced by alpha-BHC were also much greater than those induced in rats or hamsters. Male animals were more susceptible to the tumorigenic action of alpha-BHC than females. Among different strains of mice, the DDY showed greatest susceptibility and the C57BL/6 showed the least. Induction oflpha-BHC was not inhibited by concomitant feeding of 1-naphthyl isothiocyanate or p- hydroxypropiophenone. However, 3-methylcholanthrene slightly inhibited their induction by alpha-BHC.
Similar articles
-
Effect of various factors on the induction of liver tumors in animals by quinoline.Gan. 1977 Dec;68(6):785-96. Gan. 1977. PMID: 598648
-
Carcinogenicity of benzene hexachloride and its isomers.J Environ Pathol Toxicol. 1980 Sep;4(2-3):355-72. J Environ Pathol Toxicol. 1980. PMID: 6161979 Review.
-
Effect of alpha-benzene hexachloride on 2-fluorenylacetamide carcinogenesis in rats.Gan. 1978 Jun;69(3):423-6. Gan. 1978. PMID: 78868
-
Reversibility and irreversibility of liver tumors in mice induced by the alpha isomer of 1,2,3,4,5,6-hexachlorocyclohexane.Cancer Res. 1976 Jul;36(7 PT 1):2227-34. Cancer Res. 1976. PMID: 58716
-
Effect of the cell cycle on carcinogenesis.Fed Proc. 1971 Nov-Dec;30(6):1760-5. Fed Proc. 1971. PMID: 4332608 Review. No abstract available.
Cited by
-
The hemoglobin receptor protein of porphyromonas gingivalis inhibits receptor activator NF-kappaB ligand-induced osteoclastogenesis from bone marrow macrophages.Infect Immun. 2006 May;74(5):2544-51. doi: 10.1128/IAI.74.5.2544-2551.2006. Infect Immun. 2006. PMID: 16622189 Free PMC article.
-
Strain differences in N-butyl-N-(4-hydroxybutyl)nitrosamine bladder carcinogenesis in rats.Jpn J Cancer Res. 1988 Apr;79(4):453-9. doi: 10.1111/j.1349-7006.1988.tb01613.x. Jpn J Cancer Res. 1988. PMID: 3133335 Free PMC article.
-
A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines.Genetics. 2004 Jun;167(2):859-66. doi: 10.1534/genetics.103.024521. Genetics. 2004. PMID: 15238534 Free PMC article.