doi: 10.1126/science.176.4034.514.
Trophic regulation of acetylcholine sensitivity of muscle: effect of electrical stimulation
- PMID: 5032352
- DOI: 10.1126/science.176.4034.514
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Trophic regulation of acetylcholine sensitivity of muscle: effect of electrical stimulation
Science.
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Abstract
Denervation of skeletal muscle results in a spread of acetylcholine sensitivity over the entire surface membrane. Electrical stimulation, programmed to mimic the normal activity pattern, was applied continuously to the denervated rat diaphragm in vivo. After 4 days, the acetylcholine sensitivity was far less in the stimulated diaphragms than in denervated controls. Muscle activity may account for "neurotrophic" regulation of the acetylcholine sensitivity.
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