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. 1979 Sep;308(3):261-4.
doi: 10.1007/BF00501391.

Inhibition of PGE1 induced intestinal secretion by the synthetic enkephalin analogue FK 33-824

F Lembeck, E Beubler

Inhibition of PGE1 induced intestinal secretion by the synthetic enkephalin analogue FK 33-824

F Lembeck et al. Naunyn Schmiedebergs Arch Pharmacol. 1979 Sep.

Abstract

1. The effects of the enkephalin analogue, FK 33-824 were compared with those of morphine and naloxone on the prostaglandin E1-induced increase in intestinal fluid volume and unanaesthetized and pithed rats. 2. FK 33-824 inhibits the prostaglandin E1-induced increase in intestinal fluid volume both in unanaesthetized and pithed rats. 3. Naloxone abolished the inhibitory effect of FK 33-824 in both experimental models. 4. It can be concluded from the experiments in pithed rats that the inhibitory effect of FK 33-824, like that of morphine, on prostaglandin E1-induced secretion is caused by a peripheral action. 5. It is assumed that endogenous enkephalins protect against prostaglandin-mediated loss of fluid into the gut lumen. This protective effect can be mimicked by an enkephalin analogue and blocked by naloxone.

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