Carbonic anhydrase and bone remodeling: sulfonamide inhibition of bone resorption in organ culture
- PMID: 5033181
- DOI: 10.1126/science.176.4038.1031
Carbonic anhydrase and bone remodeling: sulfonamide inhibition of bone resorption in organ culture
Abstract
Five sulfonamide inhibitors of carbonic anhydrase inhibited parathyroid hormone-induced resorption of bone in organ culture. The relative activities of the sulfonamides as resorption inhibitors were such as to suggest the presence of a functional carbonic anhydrase system in bone linked to the mechanism of bone resorption.
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