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. 1972 Jun 30;176(4042):1423-5.
doi: 10.1126/science.176.4042.1423.

Salicylate: a structure-activity study of its effects on membrane permeability

H Levitan, J L Barker

Salicylate: a structure-activity study of its effects on membrane permeability

H Levitan et al. Science. .

Abstract

Salicylate atnd benzoate, and their anlalogs, reversibly increase the membrane potetntial and conductance of identified molluscan neurons by increasing potassium conductance and decreasing chloride conductance. The relative potencies of these compounds were closely correlated with their octanol-water partition coefficients and their pK(a) values.

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