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. 1972 Jun;11(2):305-9.

The mechanism of antigen-induced electrophoretic mobility reduction of guinea-pig macrophages

E A Caspary

The mechanism of antigen-induced electrophoretic mobility reduction of guinea-pig macrophages

E A Caspary. Clin Exp Immunol. 1972 Jun.

Abstract

The interaction of antigen with sensitized lymphocytes produces a protein substance capable of reducing the electrophoretic mobility of guinea-pig peritoneal macrophages. Reaction with the protein slowing factor also involves some vital synthetic activities of the macrophage. A critical number of lymphocytes is required to initiate the complete reaction suggesting that above this threshold recruitment may take place. It is suggested that the mechanism of action is a close parallel to that of macrophage migration inhibition.

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