On the theory of ion transport across the nerve membrane. V. Two models for the Cole-Moore K + hyperpolarization delay

Abstract

Two illustrative molecular models, designed to explain the Cole-Moore K(+) hyperpolarization delay, are proposed and analyzed. Both introduce a process supplementary to the usual Hodgkin-Huxley (HH) one for a K(+) channel. In both cases the new process becomes involved as a consequence of the conditioning hyperpolarization of the membrane and would account for the observed delay time in the K(+) current after depolarization to near ENa. The first model uses adsorption or desorption of phospholipid molecules on the surface of the assumed protein K(+) channel or gate. The second model involves the translocation of the charged subunits of the channel in the hyperpolarizing electric field.