The effects of oleic acid, tolbutamide, and oxyphenbutazone on the binding of warfarin by human serum albumin
- PMID: 504792
Item in Clipboard
The effects of oleic acid, tolbutamide, and oxyphenbutazone on the binding of warfarin by human serum albumin
Res Commun Chem Pathol Pharmacol.
1979 Sep.
Abstract
Equilibrium dialysis studies showed that, at low levels, stearate, palmitate and oleate enhanced the binding of warfarin by human serum albumin, but at high levels of FFA, warfarin was displaced. Tolbutamide and oxyphenbutazone separately desplaced warfarin, and this dispplacement was reduced by the presence of low concentrations of oleate while at higher concentrations of oleate displacement occurred. Thus, the binding of warfarin was affected in a complex fashion depending upon the drugs present and the concentration of the FFA.
Similar articles
-
Multiple factors affecting excretion of warfarin in rats.Res Commun Chem Pathol Pharmacol. 1977 Oct;18(2):275-81. Res Commun Chem Pathol Pharmacol. 1977. PMID: 918347
-
Evidence for the fatty acid-induced heterogeneity of the N and B conformations of human serum albumin.Biochem Pharmacol. 1985 Sep 15;34(18):3299-304. doi: 10.1016/0006-2952(85)90349-1. Biochem Pharmacol. 1985. PMID: 4038338
-
Effects of perfluorochemical emulsion components on human albumin binding of warfarin.Arch Int Pharmacodyn Ther. 1987 Aug;288(2):165-74. Arch Int Pharmacodyn Ther. 1987. PMID: 3675079
-
The location of drug binding sites in human serum albumin.Biochem Pharmacol. 1981 Apr 1;30(7):687-92. doi: 10.1016/0006-2952(81)90151-9. Biochem Pharmacol. 1981. PMID: 7018498 Review. No abstract available.
-
Newer pharmacological data on oxyphenbutazone.Jpn J Pharmacol. 1965 Jun;15(2):187-98. doi: 10.1254/jjp.15.187. Jpn J Pharmacol. 1965. PMID: 5320527 Review. No abstract available.
Cited by
-
Allosteric properties of the oxyphenbutazone--human serum albumin complex.Pharm Weekbl Sci. 1983 Oct 21;5(5):228-33. doi: 10.1007/BF02332949. Pharm Weekbl Sci. 1983. PMID: 6646989
-
Stress can affect drug pharmacokinetics via serum/tissues protein binding and blood flow rate alterations.Eur J Drug Metab Pharmacokinet. 2012 Mar;37(1):1-7. doi: 10.1007/s13318-011-0077-2. Epub 2011 Dec 16. Eur J Drug Metab Pharmacokinet. 2012. PMID: 22173744
-
Effects of Temperature on Plasma Protein Binding Ratios (PPBRs) of Enrofloxacin and Ciprofloxacin in Yellow Catfish (Pelteobagrus fulvidraco), Grass Carp (Ctenopharyngodon idella), and Largemouth Bass (Micropterus salmoides).Animals (Basel). 2023 May 25;13(11):1749. doi: 10.3390/ani13111749. Animals (Basel). 2023. PMID: 37889633 Free PMC article.
-
Variation in the binding affinity of warfarin and phenprocoumon to human serum albumin in relation to surgery.Eur J Clin Pharmacol. 1993;44(2):157-62. doi: 10.1007/BF00315474. Eur J Clin Pharmacol. 1993. PMID: 8453960
-
The role of the protein-binding on the mode of drug action as well the interactions with other drugs.Eur J Drug Metab Pharmacokinet. 2008 Oct-Dec;33(4):225-30. doi: 10.1007/BF03190876. Eur J Drug Metab Pharmacokinet. 2008. PMID: 19230595 Review.