doi: 10.1126/science.505005.
A glucose-controlled insulin-delivery system: semisynthetic insulin bound to lectin
- PMID: 505005
- DOI: 10.1126/science.505005
Item in Clipboard
A glucose-controlled insulin-delivery system: semisynthetic insulin bound to lectin
Science.
.
Abstract
A stable, biologically active glycosylated insulin derivative that is complementary to the major combining site of concanavalin A has been synthesized. Hormone release is proportional to the quantity of glucose present. Glucose regulation of exogenous insulin delivery could have important applications in the therapy of diabetes mellitus.
Similar articles
-
Glycosylated insulin complexed to Concanavalin A. Biochemical basis for a closed-loop insulin delivery system.Diabetes. 1983 Jun;32(6):499-504. doi: 10.2337/diab.32.6.499. Diabetes. 1983. PMID: 6354778
-
Effects of trypsin on binding of insulin and concanavalin A and on glucose and proline transport in the R3230AC mammary adenocarcinoma.Biochim Biophys Acta. 1982 Feb 10;720(1):42-52. doi: 10.1016/0167-4889(82)90037-4. Biochim Biophys Acta. 1982. PMID: 7037058
-
Study of the imprinting and overlap of insulin and concanavalin-A at the receptor level in a protozoan (Tetrahymena) model system.Acta Physiol Hung. 1984;64(1):19-23. Acta Physiol Hung. 1984. PMID: 6435393
-
Responsive materials for self-regulated insulin delivery.Macromol Biosci. 2013 Nov;13(11):1464-77. doi: 10.1002/mabi.201300120. Epub 2013 Jul 9. Macromol Biosci. 2013. PMID: 23839986 Review.
-
New developments in the treatment of type 1 diabetes mellitus.Exp Clin Endocrinol Diabetes. 1999;107 Suppl 3:S108-13. doi: 10.1055/s-0029-1212163. Exp Clin Endocrinol Diabetes. 1999. PMID: 10522818 Review.
Cited by
-
Non inflammatory boronate based glucose-responsive insulin delivery systems.PLoS One. 2012;7(1):e29585. doi: 10.1371/journal.pone.0029585. Epub 2012 Jan 17. PLoS One. 2012. PMID: 22272238 Free PMC article.
-
Connecting Rodent and Human Pharmacokinetic Models for the Design and Translation of Glucose-Responsive Insulin.Diabetes. 2020 Aug;69(8):1815-1826. doi: 10.2337/db19-0879. Epub 2020 Mar 9. Diabetes. 2020. PMID: 32152206 Free PMC article.
-
Insulin treatment: a non-stop revolution.Diabetologia. 1983 Sep;25(3):209-21. doi: 10.1007/BF00279931. Diabetologia. 1983. PMID: 6357909 Review. No abstract available.
-
One hundred years of insulin therapy.Nat Rev Endocrinol. 2021 Dec;17(12):715-725. doi: 10.1038/s41574-021-00542-w. Epub 2021 Aug 17. Nat Rev Endocrinol. 2021. PMID: 34404937 Review.
-
Developing Insulin Delivery Devices with Glucose Responsiveness.Trends Pharmacol Sci. 2021 Jan;42(1):31-44. doi: 10.1016/j.tips.2020.11.002. Epub 2020 Nov 26. Trends Pharmacol Sci. 2021. PMID: 33250274 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
