doi: 10.1126/science.505013.
Pyruvate dehydrogenase activation in adipocyte mitochondria by an insulin-generated mediator from muscle
- PMID: 505013
- DOI: 10.1126/science.505013
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Pyruvate dehydrogenase activation in adipocyte mitochondria by an insulin-generated mediator from muscle
Science.
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Abstract
Material in a chromatographic fraction from an extract of insulin-treated muscle stimulated pyruvate dehydrogenase activity in addipocyte mitochondria. This action was similar to insulin's activation of the enzyme in a plasma membrane-mitochondria mixture. Neither the chromatographic fraction nor insulin required adenosine triphosphate or magnesium ion (Mg2+), suggesting that both agents acted through a calcium-sensitive phosphatase. This fraction may contain a chemical mediator of insulin action.
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