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Comparative Study
. 1972 Sep 1;177(4051):808-9.
doi: 10.1126/science.177.4051.808.

Curative potencies against -amanitin poisoning by cytochrome c

G L Floersheim
Comparative Study

Curative potencies against -amanitin poisoning by cytochrome c

G L Floersheim. Science. .

Abstract

The fatalities occurring after ingestion of the poisonous mushroom Amanita phalloides are thought to be due to alpha-amanitin. Cytochrome c provided antidotal effects against a lethal dose of this toxin in mice. Significant survival was obtained even when the treatment was withheld for 8 hours. The enzyme was superior to a previously explored therapeutic regimen consisting of penicillin and its combination with chloramphenicol and sulfamethoxazole.

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