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. 1972 Aug 25;177(4050):697-9.
doi: 10.1126/science.177.4050.697.

Inhibition of bacterial adherence by secretory immunoglobulin A: a mechanism of antigen disposal

R C Williams, R J Gibbons

Inhibition of bacterial adherence by secretory immunoglobulin A: a mechanism of antigen disposal

R C Williams et al. Science. .

Abstract

Preparations of secretory iminunoglobuilin A (S-IgA) isolated from human parotid fluid specifically inhibited the adherence of Streptococcus strains to epithelial cells. Since bacterial adherence is a prerequisite for colonization of mucous surfaces. S-IgA-mediated inhibition of adherence would limit bacterial colonization. This mechanism can explain how secretory immunoglobulins function in the disposal of bacterial antigens.

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