Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1972 Jul;24(1):120-6.
doi: 10.1128/am.24.1.120-126.1972.

Influence of mouse strain on the assayed potency (unitage) of tetanus toxoid

M C Hardegree, M Pittman, C J Maloney

Influence of mouse strain on the assayed potency (unitage) of tetanus toxoid

M C Hardegree et al. Appl Microbiol. 1972 Jul.

Abstract

The assayed potency of an adsorbed tetanus toxoid C(2), relative to the international standard for tetanus toxoid (adsorbed), varied significantly with the use of different strains of mice. The unitage was highest with NIH mice, and it was not significantly different from that with CFW mice. With CDF(1) and BALB/c mice, however, the assayed potency was significantly lower than with NIH mice. C3H mice failed to respond to the dose range of the toxoids employed with the other four strains. The significance of the influence of the mouse strain on the designation of a prescribed unit requirement for tetanus toxoid, adsorbed, relative to human efficacy is discussed.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Immunol. 1959 Oct;83:448-57 - PubMed
    1. Bull World Health Organ. 1959;20:1133-50 - PubMed
    1. Bull World Health Organ. 1953;9(6):837-42 - PubMed
    1. J Immunol. 1957 Sep;79(3):238-42 - PubMed
    1. J Immunol. 1970 Apr;104(4):896-901 - PubMed

LinkOut - more resources