doi: 10.1136/bmj.1.5794.205.
Hyperlactataemia in phenformin-treated diabetics
- PMID: 5058730
- PMCID: PMC1789220
- DOI: 10.1136/bmj.1.5794.205
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Hyperlactataemia in phenformin-treated diabetics
Br Med J.
.
Abstract
Raised fasting blood lactate levels were observed in diabetic patients on phenformin in therapeutic dosage. After an intravenous glucose load this effect was exaggerated and the lactate/pyruvate ratio increased. Withdrawal of the drug led to normal blood lactate levels and a fall in the lactate/pyruvate ratio.
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