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. 1972 Jan;9(1):187-8.
doi: 10.1128/JVI.9.1.187-188.1972.

Selective inhibition of the synthesis of Sindbis virion proteins by an inhibitor of chymotrypsin

E R Pfefferkorn, M K Boyle

Selective inhibition of the synthesis of Sindbis virion proteins by an inhibitor of chymotrypsin

E R Pfefferkorn et al. J Virol. 1972 Jan.

Abstract

Treatment of chick embryo fibroblasts infected with Sindbis virus with TPCK, the choloromethyl ketone derivative of tosyl-phenylalanine and an inhibitor of chymotrypsin, resulted in reduced synthesis of viral structural proteins and the accumulation of a high-molecular-weight polypeptide, thought to be a precursor. The analogous inhibitor of trypsin, TLCK, the chloromethyl ketone derivative of tosyllysine, had no such effect.

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References

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