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. 1972 Jan;10(1):67-75.

Observations on the cytotoxicity of lymphocytes to a target cell system

I C Balfour, C A Evans, V L Middleton, G D Pegrum

Observations on the cytotoxicity of lymphocytes to a target cell system

I C Balfour et al. Clin Exp Immunol. 1972 Jan.

Abstract

It is known that after mixed culture lymphocytes exhibit an increase in cytotoxicity to a target cell. The present study was undertaken to see if the degree of cytotoxicity was also related to HL-A differences.

A cytotoxic effect was found where there was antigenic disparity. The degree was unrelated to the number of different antigens at the HL-A locus but cytotoxic effect was absent in cultures where there was complete HL-A identity using lymphocytes from twins, siblings and unrelated persons.

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References

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