The gliovascular interphase in irradiated brain tissue. Electron microscopic investigations. Horseradish peroxidase transport

Abstract

The gliovascular interphase in irradiated brain tissue. Electron microscopic investigations. Horseradish peroxidase transport. Acta physiol. pol., 1979, 30 (4): 455--468. The gliovascular junction which is the morphological element of the blood-brain barrier was studied. For damaging the barrier 44 Wistar rats received single dose of 800 rads of gamma radiation from Co60. The observations were carried out in electron microscope and capillary permeability was tested by means of horseradish peroxidase. It was found that: astrocytes play a significant role in the normal function of the barrier maintaining efficient active transport, the capillary vessel is a barrier to transport of macromolecular substances which cannot pass into the brain tissue under normal conditions.