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. 1979 Sep;31(5):601-19.

Genetic linkage between hereditary hemochromatosis and HLA

K Kravitz, M Skolnick, C Cannings, D Carmelli, B Baty, B Amos, A Johnson, N Mendell, C Edwards, G Cartwright

Genetic linkage between hereditary hemochromatosis and HLA

K Kravitz et al. Am J Hum Genet. 1979 Sep.

Abstract

A large Mormon pedigree of a proband with hemochromatosis was studied, using transferrin saturation as the quantitative phenotypic trait. The analysis indicated that the inheritance of hemochromatosis was recessive, with partial expression in some heterozygotes. The lod score of 6.88 (theta = .0) was strongly indicative of linkage between the hemochromatosis locus and the human major histocompatibility (HLA) loci.

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