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. 1972 Sep 9;3(5827):611-4.
doi: 10.1136/bmj.3.5827.611.

Interactions of benzodiazepines with warfarin

M Orme, A Breckenridge, R V Brooks

Interactions of benzodiazepines with warfarin

M Orme et al. Br Med J. .

Abstract

Administration of nitrazepam (10 mg nightly), diazepam (15 mg/day), and chlordiazepoxide (15 and 30 mg/day) had no effect on steady-state plasma warfarin concentrations, the plasma half-life of warfarin, or anticoagulant control in patients and it appears safe to prescribe these agents to patients on long-term oral anticoagulants. Urinary excretion of 6 beta-hydroxycortisol, however, increased in two out of five patients given chlordiazepoxide. In rats pretreatment with chlordiazepoxide (40 mg/kg for four days) caused stimulation of liver microsomal enzyme activity but neither diazepam nor nitrazepam had this effect.

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References

    1. Life Sci. 1965 May;4(10):1091-8 - PubMed
    1. Toxicol Appl Pharmacol. 1966 Jul;9(1):116-23 - PubMed
    1. Folia Med Neerl. 1967;10(4):141-5 - PubMed
    1. J Endocrinol. 1968 Mar;40(3):391-2 - PubMed
    1. Lancet. 1959 Nov 7;2(7106):754-8 - PubMed

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