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. 1972 Jul;27(4):398-400.
doi: 10.1136/thx.27.4.398.

A method of sterilizing and preserving fresh allograft heart valves

E Lockey, N Al-Janabi, L Gonzalez-Lavin, D N Ross

A method of sterilizing and preserving fresh allograft heart valves

E Lockey et al. Thorax. 1972 Jul.

Abstract

The present study was undertaken to find an antibiotic mixture which would rapidly and completely sterilize a heavily contaminated allograft heart valve without reducing its viability. Two different antibiotic combinations were used; formula A was used for 66 valves and formula B for 60 valves. Viability of the valves was assessed by autoradiography and tissue culture, and was found to be similar in both formulae. Formula B proved more effective; all valves were sterile after 24 hours' exposure to the antibiotics and remained so thereafter.

The period of viability was greatly extended when a nutrient medium was used to store the valves.

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References

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