Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1972 Nov;51(11):2977-80.
doi: 10.1172/JCI107123.

HL-A8: a genetic link between dermatitis herpetiformis and gluten-sensitive enteropathy

S I Katz, Z M Falchuk, M V Dahl, G N Rogentine, W Strober

HL-A8: a genetic link between dermatitis herpetiformis and gluten-sensitive enteropathy

S I Katz et al. J Clin Invest. 1972 Nov.

Abstract

Histocompatibility antigen HL-A8 was found in 58% of 26 patients with dermatitis herpetiformis (DH) compared to 24% of a normal group. This difference in antigen frequency is significant at the P < 0.003 level. In a previous study, the frequency of this same genetic marker was found to be significantly increased in patients with gluten-sensitive enteropathy (GSE) (88% in patients vs. 22% in controls). The finding of an increased incidence of the HL-A8 antigen in both DH and GSE supports the concept that these diseases are related and provides a genetic basis for the association between the two.

PubMed Disclaimer

References

    1. Lancet. 1967 Oct 7;2(7519):729-33 - PubMed
    1. Lancet. 1968 May 25;1(7552):1101-6 - PubMed
    1. Transplantation. 1968 Nov;6(8):913-27 - PubMed
    1. Trans St Johns Hosp Dermatol Soc. 1968;54(2):141-7 - PubMed
    1. Br J Dermatol. 1969 Jul;81(7):493-503 - PubMed