Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1972 Oct 28;4(5834):196-8.
doi: 10.1136/bmj.4.5834.196.

High dosage metolazone in chronic renal failure

H J Dargie, M E Allison, A C Kennedy, M J Gray
Clinical Trial

High dosage metolazone in chronic renal failure

H J Dargie et al. Br Med J. .

Abstract

Metolazone is a modified quinazolinesulphonamide and in a dose of between 4 and 7.5 mg is an effective diuretic in man with normal renal function. Fourteen patients with non-oedematous stable chronic renal failure (creatinine clearance ranging from 1.2 to 12 ml/min) were given metolazone in doses ranging from 20-150 mg. A noticeable increase in urine flow and sodium excretion occurred, free water clearance increased, and there was a small but significant increase in potassium excretion. No side effects were noted.

PubMed Disclaimer

References

    1. JAMA. 1966 Mar 21;195(12):1066-9 - PubMed
    1. Ann N Y Acad Sci. 1966 Nov 22;139(2):453-65 - PubMed
    1. Ann N Y Acad Sci. 1966 Nov 22;139(2):471-80 - PubMed
    1. Ann Intern Med. 1968 Aug;69(2):249-61 - PubMed
    1. Acta Med Scand. 1968 Dec;184(6):473-9 - PubMed

Publication types

MeSH terms

LinkOut - more resources