Transcription of the influenza ribonucleic acid genome by a virion polymerase. 3. Completeness of the transcription process
- PMID: 5084464
- PMCID: PMC356522
- DOI: 10.1128/JVI.10.4.689-697.1972
Transcription of the influenza ribonucleic acid genome by a virion polymerase. 3. Completeness of the transcription process
Abstract
The virion ribonucleic acid (RNA) polymerase of influenza strain A(0)/WS transcribed at least 81% of the viral genome in vitro. The polymerase is shown to be associated with each of the major size classes of the virion RNA-ribonucleoprotein complexes. Under optimal in vitro conditions, at least 45% of the RNA contained in a population of influenza virions was involved in a repetitive transcription process. The detectable proteins associated with enzymatically active complexes containing RNA, ribonucleoprotein, and polymerase have been identified by polyacrylamide gel electrophoresis.
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