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. 1972 Sep;46(1):151-6.
doi: 10.1111/j.1476-5381.1972.tb06857.x.

The occurrence of tolerance to a central depressant effect of nicotine

C F Morrison, J A Stephenson

The occurrence of tolerance to a central depressant effect of nicotine

C F Morrison et al. Br J Pharmacol. 1972 Sep.

Abstract

1. Rats were injected with 0.8 mg nicotine/kg, 0.8 mg amphetamine/kg or with saline immediately before being tested for 30 min in activity boxes.2. During the first 3 trials the nicotine group were less active than the controls but from trial 5 onwards nicotine had a stimulant effect. The stimulant effect of the amphetamine did not alter with repeated injection.

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References

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